ABSTRACT Nonsteroidal anti-inflammatory drugs are widely used by humans as therapeutic agents to treat or prevent illnesses. Once ingested, part of them is excreted and enters the wastewater treatment plants generating biosolids that they may be used as fertilizing complements. The purpose of this study was to investigate the mobility of nonsteroidal anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) in soils and soils amended with biosolid. Studies of NSAIDs adsorption on two different soils were carried through batch equilibrium at room temperature. The mobility of NSAIDs in soils was studied through the use of leaching columns incorporating in the top section soil enriched with NSAIDs with and without biosolid. Ketoprofen, naproxen and ibuprofen were determined in the leaching columns. Anti-inflammatory mobility in the soil profile depends on the specific characteristics of each system soil-biosolid. In both soils there was little mobility of anti-inflammatory in the soil profile. In Linderos soil were found in greater quantity of Ibuprofen, naproxen and diclofenac that in Lonquén soil.

Fármacos anti-inflamatórios não-esteroidais (NSAIDs) são um grupo de medicamentos largamente utilizados para combater certas doenças. No entanto, após o consumo, podem ser excretados em águas residuais com consequente efeito ambiental. NSAIDs são disruptores endócrinos que podem causar alterações na fisiologia animal. O objetivo deste estudo foi desenvolver um método de análise que permita a determinação da presença de NSAIDs em água. A extração do composto foi realizada por extração em fase sólida (SPE), usando um cartucho Oasis HLB. Os analitos foram analisados por cromatografia líquida de alta eficiência com detecção por arranjo de diodos (HPLC-DAD). O método foi aplicado em águas do Rio Maipo e de uma estação de tratamento de águas residuais vizinha à Região Metropolitana dos pontos de amostragem Pajaritos, Viña, Tuberia, Unión e Gansos no Chile. Este método mostrou-se adequado na determinação dos NSAIDs em amostras de água com percentagens de recuperação acima de 80%. Naproxeno e ibuprofeno foram detectados principalmente em amostras de água do Rio Maipo, com concentrações variando entre 0,33 e 0,83 µg L-1.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are a group of medications widely used by man to heal certain ailments. However, after consumption, they may be excreted in wastewaters with consequent environmental effects. NSAIDs are endocrine disruptors that can cause changes in animal physiology. The purpose of this study was to implement an analytical method that permits the determination of the presence of NSAIDs in water. Compound extraction was performed by solid-phase extraction (SPE) using an Oasis HLB cartridge. Analytes were analyzed by high-performance liquid chromatography with diode array detection (HPLC-DAD). The method was applied in water from the Maipo River and from a neighboring wastewater treatment plant in the Metropolitan Region of Pajaritos, Viña, Tuberia, Unión and Gansos sampling points in Chile. This method turned out to be adequate for the determination of NSAIDs in water samples with recovery percentages above 80%. Naproxen and ibuprofen were mostly detected in the Maipo River water samples, with concentrations ranging from 0.33 to 0.83 µg L-1.